The Big Bang Theory, Season 1

[Leonard Knocking on Penny's door]

Leonard:
Penny, are you okay?

Penny(voice off):
I'm fine, Leonard, just go away.

Leonard:
Look, I understand that breaking up with someone can be very painful--.

Penny:
GO AWAY!

Leonard:
Okay, feel better, bye. (Goes back to apartment) She doesn't want to talk.

Sheldon:
Not surprising. Penny's emotional responses originate from the primitive portion of the brain known as the Amygdala, while speech is centered in the much more recently developed Neocortex. The former can easily overpower the latter giving scientific credence to the notion of being rendered speechless. (Leonard stares at him.) Or maybe she just doesn't want to talk.