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While it’s not the first time a study has shown that early treatment with hormone replacement therapy may be more protective for a women’s brain, it did suggest for the first time that greater amounts of tau protein may be associated with later initiation of hormone treatment.
Found on CNN 1 year ago
These findings may eventually lead to the development of imaging techniques that allow us to diagnose Alzheimer’s disease earlier and more accurately.
Found on CNN 1 year ago
Markers of inflammation were (also) found, which may be an equally important marker for disease progression, the findings were also apparent in people with no or minimal cognitive symptoms, which suggests these new eye tests may be well-positioned to aid in early diagnosis.
Found on CNN 1 year ago
We don’t really want to be telling people it’s time to stop their laxative because you’re going to have dementia. That is the wrong message.
Found on CNN 1 year ago
Further study is absolutely warranted to make a definitive impact on clinical practice.
Found on CNN 1 year ago
From a health equity perspective, it’s important to say that the specific study population was 90% White, broader conclusions based on a more diverse population really have to be withheld.
Found on CNN 1 year ago
Exercise is the #1 most powerful tool in the fight against cognitive decline and dementia, people affected by multisite chronic pain may be less able to adhere to regular physical activity as one potential mechanism for increased dementia risk.
Found on CNN 1 year ago
I’ve never personally suggested someone to start drinking moderate amounts of alcohol if they were abstinent, but there’s really not a one-size-fits-all approach towards counseling a patient on alcohol consumption.
Found on CNN 1 year ago
If someone downs five drinks on Saturday and Sunday that’s 10 drinks a week so that would qualify as a moderate alcohol intake, to me, that is not that is not the same as having a glass of wine five days a week with a meal, which slows consumption.
Found on CNN 1 year ago
People don’t really monitor their pours of wine, for example, they may think they are drinking a standard-sized glass of wine, but it’s really a glass and a half every time. Drink two of those pours and they’ve had three glasses of wine. That’s no longer mild or moderate consumption.
Found on CNN 1 year ago
One has to be cautious when interpreting studies using medical records. They can be fraught with challenges in how diseases are coded and studied, any anytime you ask people to recall their behaviors, such as drinking, it leaves room for memory errors.
Found on CNN 1 year ago
In an ideal world, a portable at-home device that could offer this therapy would be the eventual goal, for now, it's cumbersome to receive these treatments, as specialized equipment is needed. It can also be time-intensive and costly as well.
Found on CNN 2 years ago
While exercise and staying mentally engaged shined through in this study, a comprehensive approach toward reducing Alzheimer's risk factors is the best recipe for success, any prevention plan should also include regular follow-up with a primary care physician, management of vascular risk factors like blood pressure, blood sugar, and cholesterol, avoiding smoking, minimizing alcohol use, prioritizing sleep, managing stress, and following a Mediterranean-style diet, among many other suggestions.
Found on CNN 2 years ago
In this study, a twofold increase in physical activity was equivalent to about 2.75 fewer years of processing speed aging in women, further, each extra cognitive activity corresponded to 13 fewer years of processing speed aging on average between women and men.
Found on CNN 2 years ago
In our work, we have found that certain people need to really commit to their exercise program to demonstrate effects on the memory domain, for example, people with one or more copies of the APOE4 genetic variant need to participate in more intense cardiovascular exercise programs, such as high-intensity interval training on a regular basis, to show positive effects.
Found on CNN 2 years ago
Perhaps MGMT is an important missing piece of the risk prediction puzzle for these women, but further studies are necessary.
Found on CNN 2 years ago
I'm excited about the future of psychedelics because of the relatively good safety profile and because these agents can now be studied in rigorous double-blinded clinical trials, then we can move from anecdotal reports of' I tripped on this and felt better' to' Try this and you will be statistically, significantly better.'.
Found on CNN 2 years ago
Neuroticism is specifically one trait that comes to mind, and past meta-analyses have also show this. Rumination and worry is linked to smaller brain volumes, it's unclear if the stress/neuroinflammation pathway drives this. A biomarker doesn't really exist for this so it's hard to prove.
Found on CNN 2 years ago
Specific traits may increase risk due to a lifetime of behaviors that predispose a person to developing cognitive decline or Alzheimer's disease, or there could be more of a direct biological role related to early disease pathology, neuroticism is specifically one trait that comes to mind, and past meta-analyses have also show this. Rumination and worry is linked to smaller brain volumes.
Found on CNN 2 years ago
This paper gives us so many more tools in our toolbox to, eventually, more precisely target Alzheimer's disease.
Found on CNN 2 years ago
People want to know,' what are my chances ?' and then' what can I do about it ?' not today, but in the near future, we'll be able to calculate a person's likelihood of developing Alzheimer's or another brain disorder in a more precise way, and that will help with precision medical and lifestyle management.
Found on CNN 2 years ago
Alzheimer's disease is a multifactorial disease, made up of different pathologies, and each person has their own road, clinicians always say,' once you've seen one person with Alzheimer's, you've seen one person with Alzheimer's.' The disease presents differently and progresses differently in different people.
Found on CNN 2 years ago
Just like any chronic disease of aging -- high cholesterol, heart attacks, strokes -- they all start silently decades before they show up. Alzheimer's disease is no different, targeting them early on is the best recipe for optimal brain health as we age.
Found on CNN 2 years ago
Having high cholesterol may not cause Alzheimer's, but it presses the fast-forward button on the disease pathology and cognitive decline, there's also a relationship between diabetes and the development of amyloid pathology.
Found on CNN 2 years ago
People can take control of their brain health by making active changes in their daily life, it's not just all about exercise, diet, sleep and stress, but it's also medical conditions that primary care doctors can help optimize and treat -- like high blood pressure, high cholesterol and diabetes.
Found on CNN 2 years ago
Cognitive engagement, socialization, physical activity and having a sense of purpose can separately, or even more so in combination, address key modifiable risk factors for cognitive decline and Alzheimer's disease dementia.
Found on CNN 2 years ago
Now the messaging was like,' Wait a minute. It worked, and it especially works if you pull all the high dosages from the two studies,' because it would take years to repeat a study, and considering the lack of available therapies to treat the pre-dementia phase, the company made an uncharacteristic decision -- to still apply to The FDA.
Found on CNN 3 years ago
The futility analyses showed the studies were most likely to fail.
Found on CNN 3 years ago
A handful of the most respected scientists and researchers in our field have completely different opinions, whatever the decision is, it's a watershed moment for the field of Alzheimer's disease.
Found on CNN 4 years ago
Regular use of the flu vaccine, especially starting at an early age, may help prevent viral infections that could cause cascading effects on the immune system and inflammatory pathways. These viral infections may trigger Alzheimers related cognitive decline.
Found on CNN 4 years ago
I wholly agree with this statement but for women in the peri-menopause and early menopause, hormone replacement therapy may sometimes be considered based on a variety of other factors.
Found on CNN 4 years ago
One of the most important and commonly overlooked modifiable factors is a high level of homocysteine in the blood.
Found on CNN 4 years ago
Those are drugs for symptomatic people with mild or worse dementia, those drugs work for symptoms but don't slow disease progression.
Found on CNN 4 years ago
People can take different roads to Alzheimer's disease, this paper helps to provide an evidence-based framework for doctors and patients to consider when managing a person's Alzheimer's risk.
Found on CNN 4 years ago
These toxic particles are so small they can make it past this barrier, or this gate, and cause neuroinflammation and cognitive decline.
Found on CNN 4 years ago
In my clinical practice, I look at the totality of evidence and then individualize recommendations for the person being cared for.
Found on CNN 4 years ago
Based on conflicting studies, I don't think at this time we can know for sure whether none versus low to moderate consumption is best in each individual person.
Found on CNN 4 years ago
This new study is important since it supports these findings and relates a larger waist size to increased dementia risk, especially in women.
Found on CNN 4 years ago
Based on emerging data from studies like this, we are now able to clarify sex differences in dementia risk, combining these findings with my clinical experience, I have seen greater impact on visceral fat on memory function in women, likely mediated by metabolic pathways.
Found on CNN 4 years ago
This supports the notion that in order to optimize memory function and learning, people need to prioritize restful activities -- most importantly adequate sleep -- to keep our' engines' running at peak performance.
Found on CNN 4 years ago
Fully understanding how a memory gets stored in the brain may help unlock secrets to optimal cognitive function.
Found on CNN 4 years ago
Fatty fish like wild salmon, sardines, albacore tuna, lake trout and mackerel are loaded with brain healthy Omega-3 fatty acids which nourish the brain cells.
Found on CNN 4 years ago
While this was a longer-term study, these results parallel findings from our clinical research in the Alzheimer's Prevention Clinic, where people who made dietary and other lifestyle changes showed cognitive improvements in 18 months, future studies will help to clarify how long a person needs to make a dietary change before seeing an impact on cognitive outcomes.
Found on CNN 4 years ago
In this study, while the Mediterranean diet overall decreased risk, the strongest factor to really move the needle was regular fish consumption.
Found on CNN 4 years ago
The next step toward improving cognitive outcomes in widowers at risk should be greater attention toward the types of interventions, support and resources that could maintain brain health, while different types of stress may not be entirely created equal, the significant impact of widowhood is one that requires further study.
Found on CNN 4 years ago
The loss of a life partner has to be among the most devastating and stressful life events, and it is thus not surprising of this impact on cognitive health, alzheimer's is not a disease with one single cause.
Found on CNN 4 years ago
The study is even more impactful in that patients had a gene that would definitely cause dementia, but they were still able to impact cognitive decline by over 55 %, it was a remarkable effect to see so early on.
Found on CNN 4 years ago
This study is important as it builds upon prior evidence that dietary intake of trans fats can increase risk of Alzheimer's dementia.
Found on CNN 5 years ago
People at risk still need to pay careful attention to nutrition labels, when it comes to nutrition labels, the fewer ingredients, the better ! Focus on natural whole food, and minimize or avoid those that are highly processed.
Found on CNN 5 years ago
Most physicians believe in the power of exercise to support overall brain health, but fewer believe that exercise can specifically impact people with early Alzheimer's, this study brings us one step closer toward teasing out the effects in people with biomarker defined Alzheimer's.
Found on CNN 5 years ago
I don't think we should lose hope, we understand that Alzheimer's is a lifestyle disease and we need to intervene early to stop the progression.
Found on CNN 5 years ago
This was the closest to the finish line and early results showed not only could we improve cognitive function but also get rid of amyloid in the brain, this was the most hopeful thing we had -- in fact I have patients who are in the study, patients that are waiting to get into the trials.Read More.
Found on CNN 5 years ago
You can't just eat a magic blueberry or follow a certain diet and think that your likelihood of Alzheimer's is going to go away, people take different roads to Alzheimer's disease and dementia.
Found on CNN 5 years ago
It's soccer ; it's ice hockey ; it's wrestling, it's any sport that has the potential for collision and head impact.
Found on CNN 6 years ago
I would call this a pilot study, the call to action would be that we need more robust longitudinal studies with a pre - and a post-assessment of more than brain imaging. The study should also measure cognitive and neurological function and look for changes.
Found on CNN 6 years ago
When that blockbuster drug comes, a test like this is what we're all looking for.
Found on CNN 9 years ago
What we're realizing is that if we can find a drug or some sort of intervention that can slow down or reverse the disease, we'll need to use that drug as early as possible, when someone starts having symptoms of memory loss, mild cognitive impairment or dementia due to Alzheimer's, it's so much more difficult to treat.
Found on CNN 9 years ago
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