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What we now know from this study, namely the JJ and the Novavax study, that antigenic variation, i.e. mutations that lead to different lineage, do have clinical consequences because as you can see, even though the long-range effect in the sense of severe disease is still handled reasonably well by the vaccines, this is a wakeup call to all of us that we will be dealing, as the virus uses its devices to evade pressure, particularly immunological pressure, that we will continue to see the evolution of mutants.