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As a major natural antioxidant in the body, uric acid has been estimated to account for more than 50 percent of the antioxidant capacity of plasma, with these potentially neuro-protective properties, uric acid has been hypothesized to protect against oxidative stress, a prominent contributor to dopaminergic neuron degeneration in Parkinson's disease, which may also play an important role in the pathogenesis of Alzheimer’s disease.