Star Trek: The Next Generation1987

[last lines]

Captain Jean-Luc Picard:
If ever we needed reminding of the importance of the Prime Directive, it is now.

Commander William T. Riker:
The Prime Directive doesn't apply. They're Human.

Captain Jean-Luc Picard:
Doesn't it? Our very presence may have damaged, even destroyed their way of life. Now, whether or not we agree with that way of life, whether they're Human or not, is irrelevant, Number One. We are responsible.

Commander William T. Riker:
We had to respond to the threat of the core fragment, didn't we?

Captain Jean-Luc Picard:
Of course we did. But in the end, we may have proved just as dangerous to that colony as any core fragment could ever have been.