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The big unknown is this: How much of that decline is due to something quirky because of the Omicron variant? Or, is this a weakness in the technology and it's not holding up? And it's very hard to sort out, all vaccines have strengths and weaknesses, and it may be that for mRNA that it does not produce durable protection. It could be that you go in, use mRNA vaccines to rapidly immunize a population, stabilize it, but then over time, you're going to have to come in with a heterologous boost that's a different technology.

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