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Dean H. Kenyon: It's an enormous problem, how you could get together in one tiny, sub-microscopic volume of the primitive ocean all of the hundreds of different molecular components you would need in order for a self-replicating cycle to be established. As so my doubts about whether amino acids could order themselves into meaningful biological sequences on their own, without pre-existing genetic material being present, just reached, I guess for me, the intellectual breaking point, sometime near the decade of the 70s.

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