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Raj Koothrappali: Has Bernadette found a cure for something?Howard Wolowitz: In a way. She was working on a dandruff shampoo that has the unfortunate side effect of horrible anal leakage.Raj Koothrappali: That's too bad. But then, is there any good anal leakage?Howard Wolowitz: On the upside, they decided to market it as a constipation remedy.Raj Koothrappali: Way to make lemonade. You know, around the corner where fudge is made.

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