Monk, Season 1

Capt. Stottlemeyer:
Excuse me, Doctor. Now, if Biederbeck is too big to get out of the room, how'd he get there in the first place? He's like a ship in a bottle.

Dr. Christiaan Vezza:
Well, when he first bought the apartment, he weighed a mere 422 pounds. He could still walk. On a good day, he could see his toes. Then his mother died, and he had a complete breakdown. He started binging. He would call restaurants and order everything on the menu. He topped out at 927 pounds. That was a decade ago. He has not left the room since.

Capt. Stottlemeyer:
Like I said, it's just not possible.