Supernatural, Season 1

Dean:
Alright, you know what? That's it! [pulls car over and turns to face Sam] This is about Jessica, isn't it? [Sam says nothing] You think that's your dirty little secret? That you killed her somehow? [Sam is silent] Sam, this has got to stop, man. I mean the nightmares and... and calling her name out in the middle of the night. It's gonna kill you. Now listen to me, it wasn't your fault. If you want to blame something, then blame the thing that killed her. [still no response from Sam] Alright, why don't you take a swing at me? I'm the one who dragged you away from her in the first place.

Sam:
I don't blame you.

Dean:
Well, you shouldn't blame yourself, 'cause there was nothing you could've done.

Sam:
I could have warned her.

Dean:
About what? You didn't know it was gonna happen. Besides, all of this isn't a secret. I know all about it. It's not gonna work with Mary anyway.

Sam:
No you don't.

Dean:
I don't what?

Sam:
You don't know all about it. I haven't told you everything.

Dean:
[looks slightly confused] What are you talking about?

Sam:
Well, it wouldn't be a secret if I told you, would it?

Dean:
[shocked] No... I don't like it. It's not gonna happen. Forget it.

Sam:
Dean, that girl back there is going to die unless we do something about it. And you know what? Who knows how many people are going to die after that? Now, we're doing this. You've got to let me do this.