Family Guy, Season 4

Stewie:
[after finding a drunk Brian sitting by a fire hydrant] Oh, God, a gutter? How cliché!

Brian:
I don't know what went wrong. I was just trying to live for the moment, you know? 'Cause life can end so abruptly and there's nothing you can do to stop it.

Stewie:
Is that why you've been on this path to self-destruction? You know, Brian, as smart as you are, you've just got to accept the fact that there are some things in life you just can't control.

Brian:
You mean, the way you can't control that messed up way that you laugh when you think something is really, really funny?

[cut to a scene of Stewie and Brian watching Hope & Faith, with Stewie laughing differently than usual]

Stewie:
Yes, and I accept that. Your problem is you think that just because you're not in control, nothing matters. Th-that YOU don't matter. But you know what? You matter to someone. [voice breaks] You matter big time... [runs off]