Grey's Anatomy, Season 3

Meredith:
[voiceover] The thing about plans is they don't take into account the unexpected, so when we're thrown a curve ball, whether it's in the OR or in life, we have to improvise. Of course, some of us are better at it than others. Some of us just have to move on to plan B and make the best of it. And sometimes what we want is exactly what we need. But sometimes, sometimes what we need is a new plan.