Grey's Anatomy, Season 4

Mark:
I really am up for a drink, you know if you, uh, need to talk.

Derek:
What would I need to talk about?

Mark:
Meredith. You were lucky, man. That girl jerked you around.

Derek:
You have no idea what you're talking about.

Mark:
Hey, I'm just... seem like you can use a friend about now.

Derek:
Meredith's mother never wanted her and her father was never man enough to hang around. She has a right to be damaged and us, together? It's a big step for her. Her best friend gets left at the altar, and all she sees now is things like this, they don't work. She panics. She wants this, but she doesn't know how to have it. And you know what? That's not her fault. So don't ever talk to me about Meredith Grey again because you do not know what you are talking about. And I don't want a friend.