Grey's Anatomy, Season 4

George:
How is he? Is he... okay?

Mama Burke:
He's Preston, he's a gentleman. So, he doesn't like to talk about it. And I just really don't know what to say to him.

George:
Maybe, um, maybe you can tell him that he dodged a bullet. Marriage is... once you're in, you're in. Burke is smart, he didn't make a mistake. A mistake that, you know, is hard to take back, which even if you want to take back you can't. So, you can tell him that.

Mama Burke:
"Once you're in, you're in." Make sure you have that engraved on your wedding ring when you get married.

George:
Oh, I'm already married.

Mama Burke:
You're already married? George O'Malley, Burke's friend, Burke's guy. Staying in a marriage out of obligation. That's no way to live, it's no way to love. And I think you know that.