Grey's Anatomy, Season 4

Meredith:
[about a dying paramedic's wife] I've never met her before, and yet I'm the person who handed her the worst day of her life. In her story that's who I am. That's who I'll always be.

Webber:
That's the job.

Meredith:
That's the job, I know.

Webber:
Look at me. This day, this day you feel helpless, this day makes all those other days when you fight to save a life and lose, this day makes you grateful that you have a chance to do anything at all. Take it in.