Grey's Anatomy, Season 4

Meredith:
[voiceover] At the end of the day the experience of practicing medicine bears little resemblance to the dream. We go into medicine because we want to save lives. We go into medicine because we want to do good. We go into medicine for the rush, for the high, for the ride. But what we remember at the end of most days are the losses, what we lie awake at night replaying is the pain we caused, the ills we couldn't cure, the lives we ruined or failed to save. The end of the day, the reality is nothing like we hope. The reality is, at the end of the day, more often than not, turned inside out and upside down.