Grey's Anatomy, Season 6

Meredith:
[voiceover] Ask most people what they want out of life and the answer is simple - to be happy. Maybe it's this expectation though of wanting to be happy that just keeps us from ever getting there. Maybe the more we try to will ourselves to states of bliss, the more confused we get - to the point where we don't recognize ourselves. Instead we just keep smiling - trying like hell to be the happy people we wish we were. Until eventually it hits us, it's been there all along. Not in our dreams or our hopes but in the known, the comfortable, the familiar.