House, Season 1

John:
You don't risk jail and your career just to save somebody who doesn't want to be saved unless you got something, anything. One thing. The reason normal people got wives and kids and hobbies, whatever, that's because they don't got that One Thing that hits them that hard and that true. I got music; you got this. The thing you think about all the time, the thing that keeps you south of normal. Yeah, makes us great, makes us the best. All we miss out on is everything else. No woman waiting at home after work with a drink and a kiss. That ain't gonna happen for us.

Dr. House:
That's why God made microwaves.

John:
Yeah. But when it's over... It's over.