House, Season 7

Cuddy:
The only time you're afraid is when you're happy. You just don't expect it to last.

House:
'Cause it doesn't.

Cuddy:
You don't know that.

House:
I've done horrible things to you. And I'll do horrible things again, to you. Because of one stupid moment with a dying girl in a pile of rubble, you think I can change. Tell me where I'm wrong.

Cuddy:
I don't want you to change. I know you're screwed up. I know you are always going to be screwed up. But you're the most incredible man I've ever known. You are always going to be the most incredible man I have ever known. So, unless you're breaking up with me, I am going home now.

[She kisses him goodbye and gets up to leave, to be held back by House grabbing her hand.]

House:
I love you.