Supernatural, Season 5

Dean:
Listen, chuckles, even if there is a God, He's either dead, and that's the generous theory-

Castiel:
He is out there, Dean.

Dean:
...or, He's up and kicking and doesn't give a rat's ass about any of us. I mean, look around you, man; the world is in the toilet! We are literally at the end of days here, and He's off somewhere drinking booze out of a coconut. Alright?

Castiel:
Enough. This is not a theological issue; it's strategic. With God's help, we can win.

Dean:
It's a pipe-dream, Cas.

Castiel:
[angrily] I killed two angels this week. That's my brothers. I'm hunted, I have rebelled, and I did it - all of it - for you. And you failed. You and your brother destroyed the world. And I lost everything, for nothing. So keep your opinions to yourself.