Supernatural, Season 5

Dean:
So what, you're just gonna walk back in, and we're gonna be the dynamic duo again?

Sam:
Look, Dean, I can do this. I can. I'm gonna prove it to you.

Dean:
Look, Sam, it doesn't matter. Whatever we do. I mean, it turns out that you and me, we're the, uh... the fire and the oil of the Armageddon. You know, on that basis alone, we should just pick a hemisphere. Stay away from each other for good.

Sam:
Dean, it does not have to be like this, we can fight it.

Dean:
Yeah, you're right, we can. But not together. We're not stronger when we're together, Sam. I think we're weaker. Because whatever we have between us; love, family, whatever it is; they are always gonna use it against us. And you know that. No, we're better off apart. We got a better chance of dodging Lucifer and Michael and this whole damn thing... if we just go our own ways.

Sam:
Dean, don't do this.

Dean:
Goodbye, Sam.