Supernatural, Season 5

[The episode opens in the form of a sitcom]

Dean:
[Narrating] Supernatural is filmed before a live studio audience.

Dean:
[Closes his fridge and looks at a cartoonishly big sandwich] I'm gonna need a bigger mouth.

Audience:
[Laughs, then cheers as Sam walks through the door]

Dean:
Hey there Sam. What's happening?

Sam:
Oh nothing, just the end of the world. [Audience laughs. Sam looks at the sandwich] You're gonna need a bigger mouth. Hey, uh, have you done your research yet?.

Dean:
Oh yeah, All kinds of research. All night.

Sam:
Yeah?

Audience:
[cheers as a bikini clad woman exits the bathroom]

Woman:
Ooh, Dean. We have some more "research" to do.[More laughter]

Sam:
Dean...

Dean:
[Extreme close-up] Son of a bitch! [More laughter and cheers]

[A cheesy opening credits sequence ensues, complete with Sam and Dean riding on a tandem bicycle and mopeds , playing pass football in a park, and hunting ghosts in a very comic fashion]