The Big Bang Theory, Season 3

[after Penny and Leonard slipped on marbles that Sheldon has spread across the floor]

Howard:
Sheldon, what the hell are you doing?

Sheldon:
Same thing I've been doing for three days. Trying to figure out why electrons behave as if they have no mass when traveling through a graphene sheet.

Bernadette:
With marbles?

Sheldon:
I needed something bigger than peas now, didn't I?

Bernadette:
Sheldon, when was the last time you got any sleep?

Sheldon:
I don't know, two, three days? Not important. I don't need sleep. I need answers. I need to determine where, in this swamp of unbalanced formulas squateth the toad of truth.

Penny:
[aside to Leonard] The toad of truth? Is that a physics thing?

Leonard:
No, that's a crazy thing.

Bernadette:
[making her way to Sheldon] Okay, Sheldon, what happens to our neuro-receptors when we don't get enough REM sleep?

Sheldon:
[looks at Bernadette] They lose their sensitivity to seratonin and norepinephrine.

Bernadette:
Which leads to...?

Sheldon:
Impaired cognitive function.

Bernadette:
Right. [firmly, pointing at his bedroom] So march in there, brush your teeth and go to bed!

Sheldon:
[in a childish manner] ...But I don't wanna go to bed.

Bernadette:
[firmly] I'm gonna count to three. One...

Sheldon:
[exasperated] Oh, alright! [leaves]

Leonard:
[shocked] That was amazing how you handled him.

Bernadette:
I know how to deal with stubborn children. My mother used to run an illegal daycare center in our basement.