The Big Bang Theory, Season 5

Amy:
I can stop pretending that some beautiful girl and her cute-in-the-right-light friend want to hang out with me.

Bernadette:
Amy, we're really sorry.

Penny:
Yeah, we feel awful.

Amy:
Don't. I'll be okay. You're not the first girls I thought were friends with me who ended up shunning me. It's like elementary school, junior high, high school, undergrad, grad school, and that semester abroad in Norway all over again.

Penny:
Oh, come on, Amy.

Amy:
You don't get it. [holding a piece of brain] Look at this brain.

Penny:
[getting sick] I don't really want to.

Amy:
This is us. Bernadette, you're the analytical, scientific left hemisphere. Penny, you're the creative, spontaneous right hemisphere. And where's Amy? [Lays the brain on a tray, picks up a tumor with a knife and holds it up] She's right here-the sad little tumor no one wants to go dress shopping with.

Bernadette:
Amy, you're not a tumor. Penny, tell her she's not a tumor.

[Penny is throwing up in a garbage can]