The Big Bang Theory, Season 6

Amy Farrah Fowler:
The monkey in my tobacco study has taken to smoking a pipe. I'm supposed to remove his brain to examine, but it's hard because now he reminds me of my uncle. [looks at Sheldon, who just nods silently] You've been awfully quiet tonight. Is everything okay?

Sheldon Cooper:
I'm fine.

Amy:
Alright, so how was work today? Did you exchange your research with Kripke?

Sheldon:
Yes.

Amy:
Sheldon, what's wrong?

Sheldon:
I read his research; it's leaps and bounds ahead of mine. Which means the mommy of the smartest physicist in the university is not my mommy as I had thought. It's his mommy! [starts crying]

Amy:
Sheldon, I wish there was something I could do to make you feel better. May I offer you a consoling hug?

Sheldon:
What do we have to lose?

[Amy hugs him tightly]

Amy:
How's that?

Sheldon:
I feel like I'm being strangled by a boa constrictor. [Amy lets go] Why did you stop?! [Amy hugs him again]