The Big Bang Theory, Season 6

Penny:
Sheldon, can I ask you a question?

Sheldon:
Of course.

Penny:
You ever gonna sleep with Amy?

[Leonard and Sheldon just stare at her]

Sheldon:
That's awfully personal.

Leonard:
[a little scared] We don't ask Sheldon things like that.

Penny:
Maybe you don't, I do. What's the deal?

Sheldon:
Well, word around the university is I'm giving her sex organs a proper jostling.

Penny:
All right, come on. Be serious. Look, you guys have been going out a long time. She would clearly like to have a physical relationship with you, so what are you doing?

Leonard:
All right, we're down the rabbit hole. What are you doing?

Sheldon:
Well, first of all, I'm quite fond of Amy.

Penny:
Then what's the problem?

Sheldon:
Penny, all my life, I have been uncomfortable with the sort of physical contact that comes easily to others-handshaking, hugging, prostate exams. But I'm working on it, you know? Just recently, I had to put VapoRub on Amy's chest. A year ago, that would've been unthinkable.

Leonard:
Now you know how I feel when I have to put it on you.

Penny:
Okay, hang on. Are you saying someday you and Amy might...actually get physical?

Sheldon:
[long pause] It's a possibility.

Penny:
[silently, grabbing Leonard's shoulder] Oh, my God! Sheldon, I know this wasn't easy for you, and I'm really glad we could have this conversation.

Sheldon:
Oh, yeah.