South Park, Season 12

Kyle:
Thank you for seeing us, Mr. Johnson. We were hoping that maybe you have some kind of key that can help us with our disease.

Magic:
You boys both have the virus? Are you sure?

Cartman:
We're not just sure, we're HIV-positive.

Kyle:
Will you stop it with that?! What part of this is funny to you?

Cartman:
Kyle, we need to try and find a--

Kyle:
What part of being infected with a deadly disease do you find funny?

Cartman:
I don't think it's funny, Kyle.

Kyle:
Then stop saying that you're not just sure, you're HIV-positive! This isn't funny, AIDS isn't funny, dying isn't funny, so shut the fuck up!

Cartman:
Well, excuse me, Kyle, for trying to keep some optimism, you know? I mean, sometimes when things seem their darkest you just need to try and stay..... HIV-positive, but if you wanna be so HIV-negative all the time, I--

Kyle:
Knock it off! Right now! This isn't funny! At all!

Cartman:
[pause] Are you sure?

Kyle:
YES!

Cartman:
[longer pause] Are you HIV-positive? [Kyle punches him in the face] Ow! Fuck, Kyle!